The Leiden Thrombophilia Study (LETS)

The Leiden Thrombophilia Study (LETS).

Our study grew from an attempt to solve a controversy. In 1987 protein C antigen level was assessed in a large cohort of healthy blood donors (1). Subjects in this cohort who were heterozygous for protein C deficiency did not suffer from venous thromboembolism. Family studies in four of the protein C deficient individuals showed autosomal inheritance of the defect. These findings seemed in cont...

Factor VII and fibrinogen levels as risk factors for venous thrombosis. A case-control study of plasma levels and DNA polymorphisms--the Leiden Thrombophilia Study (LETS).

The plasma levels of coagulation factor VII and fibrinogen are well known risk factors for arterial thrombosis. We tested the hypothesis that this association also exists for venous thrombosis. Additionally, MspI and HaeIII polymorphisms in the factor VII and fibrinogen genes have recently been reported to be associated with the concentration of both proteins in the plasma. However, no conclusi...

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden Mutation Causing Thrombophilia

It has autosomal dominant inheritance and is the most common cause of inherited thrombophilia. FVL is the most prevalent thrombotic risk factor known in the Caucasian population (around 5%). [1] Heterozygotes have a three to five times increased risk of thrombosis. Homozygotes are much less common but have a much higher thrombotic risk, around eight times increased risk. It leads to a hypercoag...

Factor V Leiden in young patients with thrombophilia.